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Active Ingredient: Trazodone

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Desyrel is used for treating depression. It may also be used for relief of an anxiety disorder (eg, sleeplessness, tension), chronic pain. Desyrel is an antidepressant. It is thought to increase the activity of one of the brain chemicals (serotonin), which helps elevate mood.


Use Desyrel as directed by your doctor.

  • Take Desyrel shortly after a meal or light snack.
  • It may take 1 to 4 weeks for Desyrel to work. Do not stop taking Desyrel without checking with your doctor.
  • If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up. If more than one dose is missed, restart medication and advise your doctor or pharmacist at your next appointment.

Ask your health care provider any questions you may have about how to use Desyrel.


Store Desyrel at room temperature, between 68 and 77 degrees F (20 and 25 degrees C) in a tight, light-resistant container. Store away from heat, moisture, and light. Protect from temperatures above 104 degrees F (40 degrees C). Do not store in the bathroom. Keep Desyrel out of the reach of children and away from pets.


Active Ingredient: Trazodone HCl.

Safety information

Do NOT use Desyrel if:

  • you are allergic to any ingredient in Desyrel or nefazodone
  • you are taking sodium oxybate (GHB).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Desyrel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart disease including irregular heartbeat or have had a heart attack
  • if you have a history of depression or suicidal tendencies
  • if you are scheduled to have surgery
  • if you consume alcoholic beverages.

Some medicines may interact with Desyrel. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carbamazepine, ethanol, ginkgo biloba, HIV protease inhibitors (eg, ritonavir), phenothiazines (eg, thioridazine), or serotonin reuptake inhibitors (eg, fluoxetine) because side effects, such as increased drowsiness or blurred vision, may occur
  • Buspirone, carbamazepine, digoxin, hydantoins (eg, phenytoin), itraconazole, ketoconazole, nefazodone, serotonin reuptake inhibitors (eg, fluoxetine), or sodium oxybate (GHB) because the risk of their side effects may be increased by Desyrel
  • Anticoagulants (eg, warfarin) because they may decrease Desyrels effectiveness. Your doctor may want to adjust your dose while taking Desyrel.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Desyrel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Desyrel may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Desyrel with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Desyrel it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Tell your doctor or dentist that you take Desyrel before you receive any medical or dental care, emergency care, or surgery.
  • Desyrel should not be used in children younger 6 years safety and effectiveness in these children have not been confirmed.
  • Desyrel may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems, such as impotence. Contact your doctor right away if this happens.
  • Pregnancy and breast-feeding: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Desyrel while you are pregnant. Desyrel is found in breast milk. If you are or will be breast-feeding while you use Desyrel, check with your doctor. Discuss any possible risks to your baby.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Blurred vision constipation decreased appetite dizziness drowsiness dry mouth general body discomfort headache incoordination light-headedness muscle aches/pains nausea nervousness sleeplessness stomach pain stuffy nose swelling of the skin tiredness tremors.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash hives itching difficulty breathing tightness in the chest swelling of the mouth, face, lips, or tongue) blood in urine chest pain fainting hallucinations irregular heartbeat light-headedness when rising from a lying or seated position prolonged, inappropriate, or painful erections seizures shortness of breath stroke vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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