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Xenical is an oral weight loss medication used to help obese people lose weight and keep this weight off.

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Xenical is used for managing obesity in adults and adolescents 12 years old and older. It is also used to reduce the risk of weight regain after previous weight loss. Xenical is a gastrointestinal lipase inhibitor. It works by inhibiting the digestion of fats from the diet and should be used with a reduced-calorie diet.


Use Xenical as directed by your doctor.

  • Take Xenical by mouth with or up to 1 hour after each main meal that contains fat (up to 3 per day).
  • If a meal is missed or contains no fat, do not take a dose of Xenical.
  • You can take Xenical in conjunction with a mildly reduced-calorie diet up to 3 times a day. Each time you take Xenical, your meal should contain no more than about 30% of calories from fat.
  • You should take a multivitamin supplement containing vitamins A, D, E, and K to ensure good nutrition. The supplement should be taken at least 2 hours before or after you take Xenical, such as at bedtime.
  • If you also take a thyroid hormone (eg, levothyroxine), do not take it within 4 hours before or after Xenical. Check with your doctor if you have questions.
  • If you also take cyclosporine, do not take it within 2 hours before or after Xenical. Check with your doctor if you have questions.
  • If you miss a dose of Xenical, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.


The recommended dose is one 120 mg capsule by mouth with liquid at each main meal that contains fat. Doses greater than 120 mg three times a day have not been shown to provide an additional weight loss benefit.

You should try to follow a healthy eating plan such as the one developed by the American Heart Association. Following this eating plan will help you lose weight while decreasing some of the possible gastrointestinal effects you may experience while taking Xenical.

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